Fatigue is often listed as a contributing factor in accident reports, but the ASN database does not include any fatal accidents where fatigue is cited as the primary cause. Still, it is an internationally recognized issue related to the broader issue of fitness for duty. The reduction of fatigue-related accidents is on the NTSB’s 2017-2018 Most Wanted List.
Duty/Rest Guidelines for Business Aviation (NBAA/FSF)
Fatigue Risk Management (FAA)